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Five Ways to Fight the Swine Flu
View the Swine Flu video here.
Winter in North America brings with it yearly uninvited guests- flu bugs- multiple strains of illness causing viruses just waiting for new bodies to infect. The most common recommendation has been to protect yourself with a flu vaccine. But with virtually all the US flu suddenly resistant to the leading antiviral Tamiflu, health officials are worried about where this could lead. Here are some key guidelines you MUST know if you want to survive this year’s flu season.
How can you distinguish a cold from the flu? First understand that colds are minor infections of the nose and t...
Source: Dr. Donna, MedicineWoman - January 25, 2009 Category: Medical Scientists Authors: Dr. Donna Tags: breaking news Personal Health public health flu influenza pandemic prevention swine flu tamiflu treatment Source Type: blogs
Synchronous removal of ammonium and phosphate from swine wastewater by two agricultural waste based adsorbents: Performance and mechanisms.
Abstract
Two agricultural wastes, Chinese medicinal herbal residue and spent Pleurotus ostreatus substrate, were developed to remove ammonium and phosphate from swine wastewater. These adsorbents were mesoporous materials with abundant smooth layered pores, and rough protuberances and grooves, respectively. Their adsorption capacities were 1131.65 and 1631.79 mg N g-1, and 63.41 and 62.58 mg P g-1 at pH 8.0, dosage of 0.2 g L-1 and contact time of 360 min. And kinetics data of ammonium and phosphate fitted best with the intra-particle diffusion and pseudo-second-order models, respectively. Based on the po...
Source: Bioresource Technology - March 19, 2020 Category: Biotechnology Authors: Feng C, Zhang S, Wang Y, Wang G, Pan X, Zhong Q, Xu X, Luo L, Long L, Yao P Tags: Bioresour Technol Source Type: research
Molecules, Vol. 28, Pages 170: Berbamine Hydrochloride Inhibits African Swine Fever Virus Infection In Vitro
In this study, berbamine hydrochloride, a natural bis-benzylisoquinoline alkaloid isolated from the traditional Chinese herb Berberis amurensis, showed significant antiviral activity against ASFV. The 50% cytotoxic concentration (CC50) of berbamine hydrochloride in porcine alveolar macrophages (PAMs) was 27.89 μM. The antiviral activity assay demonstrated that berbamine hydrochloride inhibits ASFV in a dose-dependent manner. In addition, a 4.14 log TCID50 decrease in the viral titre resulting from non-cytotoxic berbamine hydrochloride was found. Moreover, the antiviral activity of berbamine hydrochloride was mai...
Source: Molecules - December 25, 2022 Category: Chemistry Authors: Junhai Zhu Lihong Huang Fei Gao Weijun Jian Huahan Chen Ming Liao Wenbao Qi Tags: Article Source Type: research
Toosendanin suppresses African swine fever virus replication through upregulating interferon regulatory factor 1 in porcine alveolar macrophage cultures
In this study, we revealed that TSN exhibited a potent inhibitory effect on ASFV GZ201801-38 strain in porcine alveolar macrophages (PAMs; EC50 = 0.085 μM, SI = 365) in a dose-dependent manner. TSN showed robust antiviral activity in different doses of ASFV infection and reduced the transcription and translation levels of ASFV p30 protein, viral genomic DNA quantity as well as viral titer at 24 and 48 h post-infection. In addition, TSN did not affect virion attachment and release but intervened in its internalization in PAMs. Further investigations disclosed that TSN played its antiviral role by upregulating t...
Source: Frontiers in Microbiology - August 30, 2022 Category: Microbiology Source Type: research
Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF- κB signaling pathway
African swine fever (ASF) is an acute infectious haemorrhagic fever of pigs caused by African swine fever virus (ASFV). Aloe-emodin (Ae) is an active ingredient of Chinese herbs with antiviral, anticancer, and...
Source: Virology Journal - July 19, 2023 Category: Virology Authors: Yizhuo Luo, Yunlong Yang, Wenru Wang, Qi Gao, Ting Gong, Yongzhi Feng, Dongdong Wu, Xiaoyu Zheng, Guihong Zhang and Heng Wang Tags: Research Source Type: research
Comparative analysis of web search trends between experts and public for medicinal herbs in Korea
Conclusion This study presents meaningful results concerning the similarities and differences in interest between experts and public for popular medicinal herbs in Korea. Contrary to the common assumption that there exists big different interest between experts and public, this study revealed that there is apparent similar interest between experts and public on popular medicinal herbs in Korea. Graphical abstract
Source: Journal of Ethnopharmacology - November 28, 2015 Category: Drugs & Pharmacology Source Type: research
Search for Anti-angiogenic Substances from Natural Sources.
Abstract
As angiogenesis is critical for tumor growth and metastasis, potent and selective anti-angiogenic agents with novel modes of action are highly needed for anti-cancer drug discovery. In this review, our studies focusing on the search for anti-angiogenic substances from natural sources, such as bastadins, globostellatic acid X methyl esters and cortistatins from marine sponges, and pyripyropenes from marine-derived fungus, together with senegasaponins from medicinal plant, are summarized.
PMID: 26833441 [PubMed - in process]
Source: Chemical and Pharmaceutical Bulletin - February 3, 2016 Category: Drugs & Pharmacology Authors: Kotoku N, Arai M, Kobayashi M Tags: Chem Pharm Bull (Tokyo) Source Type: research
Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - September 22, 2021 Category: Drugs & Pharmacology Source Type: research
Chemometrics‐based approach to feature selection of chromatographic profiles and its application to search active fraction of herbal medicine
Abstract
In our previous report (J Pharmaceut Biomed 56 (2011) 443‐447), a support vector machine (SVM) based pharmacodynamic model was established for predicting active fractions of herbal medicines (HMs), where information contents embedded in the chromatograms of the fractions were represented with the peak areas. However, in this representation the global characteristics of the chromatograms were completely missed, which is definitely contrary to the global and holistic views in theories of HMs and undoubtedly reduce the success rate of this model. In order to deal with the challenge, two chemometrics methods, i.e. m...
Source: Chemical Biology and Drug Design - February 1, 2013 Category: Biology Authors: Chao Chen, Jie Yuan, Xiao‐Jie Li, Zhi‐Bin Shen, Dao‐Hai Yu, Jun‐Fang Zhu, Fan‐Lin Zeng Tags: Research Article Source Type: research
Enhancing a search for traditional medicinal plants with anthelmintic action by using wild type and stress reporter Caenorhabditis elegans strains as screening tools.
This study aimed to test whether their nematocidal activities could be confirmed in vitro using highly standardised Caenorhabditis elegans models. We applied eight different ethanol solubilised plant extracts and two commercial anthelmintic drugs to larval and adult stages of C. elegans in vitro. Seven C. elegans strains were evaluated, one wild type and six strains with GFP-tagged stress response pathways to help characterise and compare the pathways affected by plant extracts. Our in vitro screen confirmed that both of the commercial anthelmintic drugs and five of the eight traditionally used plant extracts had significa...
Source: International Journal for Parasitology - February 26, 2014 Category: Parasitology Authors: Kumarasingha R, Palombo EA, Bhave M, Yeo TC, Lim DS, Tu CL, Shaw JM, Boag PR Tags: Int J Parasitol Source Type: research
Utilization of matrix-assisted laser desorption/ionization imaging mass spectrometry to search for cannabis in herb mixtures.
Abstract
Herb mixtures including cannabis among the other herbs have recently appeared. When cannabinoids from herb extracts are detected by chemical examinations such as gas chromatography/mass spectrometry, forensic analysts have to determine whether cannabis is actually in the mixture or the cannabinoids are spiked. Morphological examinations are time-consuming, since it is difficult to find several pieces of cannabis among a large number of herb pieces using a microscope. Here, we propose a procedure for efficiently searching for cannabis in herb mixtures using matrix-assisted laser desorption/ionization imagi...
Source: Analytical and Bioanalytical Chemistry - May 18, 2014 Category: Chemistry Authors: Kuwayama K, Yamamuro T, Tsujikawa K, Miyaguchi H, Kanamori T, Iwata YT, Inoue H Tags: Anal Bioanal Chem Source Type: research
Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants.
Abstract
Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPARγ agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed...
Source: Biological and Pharmaceutical Bulletin - June 7, 2014 Category: Drugs & Pharmacology Authors: Matsuda H, Nakamura S, Yoshikawa M Tags: Biol Pharm Bull Source Type: research
Molecules, Vol. 20, Pages 14118-14138: Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases
Sleeping sickness, Chagas disease, Leishmaniasis, and Malaria are infectious diseases caused by unicellular eukaryotic parasites (“protozoans”). The three first mentioned are classified as Neglected Tropical Diseases (NTDs) by the World Health Organization and together threaten more than one billion lives worldwide. Due to the lack of research interest and the high increase of resistance against the existing treatments, the search for effective and safe new therapies is urgently required. In view of the large tradition of natural products as sources against infectious diseases [1,2], the aim of the present study is to ...
Source: Molecules - August 4, 2015 Category: Chemistry Authors: Núria MontesinoMarcel KaiserReto BrunThomas Schmidt Tags: Article Source Type: research
Clinical Search for Undiagnosed Mesenteric Phlebosclerosis at Outpatient Departments Specializing in Herbal (Kampo) Medicine.
Conclusion We detected the latent and undiagnosed MP cases. All diagnoses were made while paying careful attention to any slight changes in colonoscopy and CT scans.
PMID: 26984071 [PubMed - in process]
Source: Internal Medicine - March 18, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research
Medicinal plants in the diet of woolly spider monkeys (Brachyteles arachnoides, E. Geoffroy, 1806) – a bio-rational for the search of new medicines for human use?
ABSTRACT The present study aimed to compare the plant food diet of woolly spider monkeys (Brachyteles arachnoides) inhabiting Intervales State Park in S ão Paulo, Brazil, with medicinal plant species used by humans in the surrounding areas of the park. The diet of a group of woolly spider monkeys living in an Atlantic forest area was recorded during 43 months of fieldwork. Fifty-three species (87 food items) were recorded. Plant specimens were coll ected and identified at the University of São Paulo and the Botanical Institute of São Paulo State. Using semi-structured interviews, ethnomedicinal data were also collected ...
Source: Revista Brasileira de Farmacognosia - April 28, 2017 Category: Drugs & Pharmacology Source Type: research
